Pace's sports teams are called the Setters; the University's mascot is the Setter. Pace University sponsors 19 intercollegiate varsity sports. Pace's affiliations include the National Collegiate Athletic Association (NCAA - Division II), Northeast-10 Conference, and Eastern College Athletic Conference (ECAC). The school's official colors are blue and gold.

Pace's athletic facilities are highlighted by the Goldstein Fitness Center, which boasts a 2,400-seat arena, eight-lane swimming pool, weight/fitness room, aerobics/dance room, training room, locker rooms, equipment room, meeting rooms, offices of the athletics department and the university's health care center.