Even though Walla Walla is located on the edge of the Eastern Washington desert, the 78 acre (316,000 m²) park-like campus includes streams, beautiful landscaping, record holding trees and numerous outdoor sculptures. Boyer Avenue divides the core campus area with most dormitories and special interest houses to the south of the avenue and academic buildings to the north between Boyer Ave. and Isaacs Ave. Academic facilities surround Ankeny Field and the field provides a social focal point for the school. College Creek meanders through the main campus forming ponds and providing habitat for water fowl.

Four women’s sororities are housed in the Prentiss Hall school dormitory and four men's fraternities are housed in fraternity houses north of Isaacs Ave. Downtown Walla Walla is a few blocks to the west of the campus. The college also has other land holdings outside the main campus area, many of which are used for academic and social retreats.

The outlying areas are known for natural springs, rolling wheat fields, wineries and other agricultural features.

Most dormitories date to the early 1900’s and are of classical architectural design. About 70% of the student body reside in school housing. Academic facilities are newer and of more modern design.